What worst Covid-19 cases tell about biological patterns, scientists reveal


Scientists are beginning to untangle one of the most complex biological mysteries of the coronavirus pandemic: Why do some people get severely sick, whereas others quickly recover?

In certain patients, according to a flurry of recent studies, the virus appears to make the immune system go haywire.

Unable to marshal the right cells and molecules to fight off the invader, the bodies of the infected instead launch an entire arsenal of weapons — a misguided barrage that can wreak havoc on healthy tissues, experts said.

“We are seeing some crazy things coming up at various stages of infection,” said Akiko Iwasaki, an immunologist at Yale University who led one of the new studies.

Researchers studying these unusual responses are finding patterns that distinguish patients on the path to recovery from those who fare far worse. Insights gleaned from the data might help tailor treatments to individuals, easing symptoms or perhaps even vanquishing the virus before it has a chance to push the immune system too far.

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